Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B

被引：19

作者：

Schultz, D

Litt, M

Smith, L

Thayer, M

McCormack, K

机构：

[1] OREGON HLTH SCI UNIV,DEPT MOLEC & MED GENET,PORTLAND,OR 97201

[2] OREGON HLTH SCI UNIV,DEPT BIOCHEM & MOLEC BIOL,PORTLAND,OR 97201

[3] UNIV WISCONSIN,DEPT GENET,MADISON,WI 53706

来源：

GENOMICS | 1996年 / 31卷 / 03期

关键词：

D O I：

10.1006/geno.1996.0065

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The gating properties and current amplitudes of mammalian voltage-activated Shaker potassium channels are modulated by at least two associated beta subunits (KV beta 1.1 and KV beta 1.B). The human Kv beta 1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hybrid mapping. More precise localization of KCNA1B to 3q26.1 was obtained with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kv beta 1.2 gene (KCNA2B) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3. (C) 1996 Academic Press, Inc.

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页码：389 / 391

页数：3

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