Molecular mechanisms regulating NETosis in infection and disease

被引：243

作者：

Branzk, Nora ^{[1
]}

Papayannopoulos, Venizelos ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2013年 / 35卷 / 04期

基金：

英国医学研究理事会;

关键词：

NEUTROPHIL EXTRACELLULAR TRAPS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GROUP-A STREPTOCOCCUS; CYSTIC-FIBROSIS; CANDIDA-ALBICANS; HOST-DEFENSE; ANTIMICROBIAL ACTIVITY; HISTONE DEIMINATION; LEUKOCYTE ELASTASE; CATHEPSIN-G;

D O I：

10.1007/s00281-013-0384-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.

引用

页码：513 / 530

页数：18

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