Autopsy-proven, sporadic pick disease with onset at age 25 years

被引:3
作者
Coleman, LW
Digre, KB
Stephenson, GM
Townsend, JJ
机构
[1] Univ Utah, Hlth Sci Ctr, Dept Pathol, Salt Lake City, UT 84132 USA
[2] Univ Utah, Hlth Sci Ctr, Dept Neurol, Salt Lake City, UT 84132 USA
[3] Univ Utah, Hlth Sci Ctr, Dept Psychiat, Salt Lake City, UT 84132 USA
关键词
D O I
10.1001/archneur.59.5.856
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Context: Pick disease is uncommon and accounts for less than 2% of adult-onset dementias. Reports of Pick disease in young adults have apparently increased in the last decade. Objective: To document the presentation and course of a patient with tau-positive Pick disease presenting at an extremely young age. Setting: A university hospital. Patient: A white woman with cognitive impairment that began at age 25 years. She experienced progressive dementia over an 8-year period with radiographic evidence of severe cerebral atrophy of the frontotemporal lobes. Autopsy findings confirmed the diagnosis of Pick disease characterized by tau-positive Pick bodies in the neurons of the fascia dentata. Conclusion: Pick disease should be considered in the differential diagnosis of young adults presenting with behavioral symptoms, especially those of frontal impairment.
引用
收藏
页码:856 / 859
页数:4
相关论文
共 10 条
[1]  
Alvarez XA, 1998, EUR J NEUROL, V5, P519
[2]  
Dickson DW, 1998, BRAIN PATHOL, V8, P339
[3]  
ESIRI MM, 1997, GREENFIELDS NEUROPAT, V2, P192
[4]   A case of sporadic Pick disease with onset at 27 years [J].
Jacob, J ;
Revesz, T ;
Thom, M ;
Rossor, MN .
ARCHIVES OF NEUROLOGY, 1999, 56 (10) :1289-1291
[5]  
Kobayashi K, 1999, CLIN NEUROPATHOL, V18, P240
[6]  
Löwenberg K, 1939, ARCH NEURO PSYCHIATR, V41, P1004
[7]   Genealogic and clinicopathologic study of Pick's disease [J].
Malamud, N ;
Waggoner, RW .
ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1943, 50 (03) :288-303
[8]   SPORADIC PICKS DISEASE IN A 28-YEAR-OLD WOMAN [J].
MOWADAT, HR ;
KERR, EE ;
STCLAIR, D .
BRITISH JOURNAL OF PSYCHIATRY, 1993, 162 :259-262
[9]   Pick's disease: A clinical overview [J].
Rossor, TN .
NEUROLOGY, 2001, 56 (11) :S3-S5
[10]  
STEWART JT, 1992, J CLIN PSYCHIAT, V53, P380