Nanosized zinc oxide particles induce neural stem cell apoptosis

被引：292

作者：

Deng, Xiaoyong ^{[1
]}

Luan, Qixia ^{[1
]}

Chen, Wenting ^{[2
]}

Wang, Yanli ^{[2
]}

Wu, Minghong ^{[1
,2
]}

Zhang, Haijiao ^{[1
]}

Jiao, Zheng ^{[1
]}

机构：

[1] Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China

来源：

NANOTECHNOLOGY | 2009年 / 20卷 / 11期

关键词：

ESCHERICHIA-COLI; OLFACTORY SYSTEM; IN-VITRO; NANOPARTICLES; TOXICITY; ZNO; MECHANISM; CYTOTOXICITY; SUSPENSIONS; SOLUBILITY;

D O I：

10.1088/0957-4484/20/11/115101

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Given the intensive application of nanoscale zinc oxide (ZnO) materials in our life, growing concerns have arisen about its unintentional health and environmental impacts. In this study, the neurotoxicity of different sized ZnO nanoparticles in mouse neural stem cells (NSCs) was investigated. A cell viability assay indicated that ZnO nanoparticles manifested dose-dependent, but no size-dependent toxic effects on NSCs. Apoptotic cells were observed and analyzed by confocal microscopy, transmission electron microscopy examination, and flow cytometry. All the results support the viewpoint that the ZnO nanoparticle toxicity comes from the dissolved Zn2+ in the culture medium or inside cells. Our results highlight the need for caution during the use and disposal of ZnO manufactured nanomaterials to prevent the unintended environmental and health impacts.

引用

页数：7

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