Roles for MicroRNAs in Conferring Robustness to Biological Processes

被引：1365

作者：

Ebert, Margaret S. ^{[1
,2
]}

Sharp, Phillip A. ^{[1
,2
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

CELL | 2012年 / 149卷 / 03期

基金：

美国国家卫生研究院;

关键词：

3' UNTRANSLATED REGIONS; NEGATIVE FEEDBACK LOOP; MESSENGER-RNAS; GENE-EXPRESSION; CAENORHABDITIS-ELEGANS; REGULATORY CIRCUITS; MAMMALIAN MICRORNAS; CANCER-CELLS; FAMILY; NOISE;

D O I：

10.1016/j.cell.2012.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as post-transcriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and attenuating aberrant transcripts, and they may in some network contexts help suppress random fluctuations in transcript copy number. These activities have important consequences for normal development and physiology, disease, and evolution. Here, we will discuss examples and principles of miRNAs that contribute to robustness in animal systems.

引用

页码：515 / 524

页数：10

共 87 条

[1] The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans [J].

Abbott, AL ;

Alvarez-Saavedra, E ;

Miska, EA ;

Lau, NC ;

Bartel, DP ;

Horvitz, HR ;

Ambros, V .

DEVELOPMENTAL CELL, 2005, 9 (03) :403-414

[2] Stochastic switching as a survival strategy in fluctuating environments [J].

Acar, Murat ;

Mettetal, Jerome T. ;

van Oudenaarden, Alexander .

NATURE GENETICS, 2008, 40 (04) :471-475

[3] Target mRNA abundance dilutes microRNA and siRNA activity [J].

Arvey, Aaron ;

Larsson, Erik ;

Sander, Chris ;

Leslie, Christina S. ;

Marks, Debora S. .

MOLECULAR SYSTEMS BIOLOGY, 2010, 6

[4] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[5] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[6] Phenotypic consequences of promoter-mediated transcriptional noise [J].

Blake, William J. ;

Balazsi, Gbor ;

Kohanski, Michael A. ;

Isaacs, Farren J. ;

Murphy, Kevin F. ;

Kuang, Yina ;

Cantor, Charles R. ;

Walt, David R. ;

Collins, James J. .

MOLECULAR CELL, 2006, 24 (06) :853-865

[7] Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template [J].

Bleris, Leonidas ;

Xie, Zhen ;

Glass, David ;

Adadey, Asa ;

Sontag, Eduardo ;

Benenson, Yaakov .

MOLECULAR SYSTEMS BIOLOGY, 2011, 7

[8] A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition [J].

Bracken, Cameron P. ;

Gregory, Philip A. ;

Kolesnikoff, Natasha ;

Bert, Andrew G. ;

Wang, Jun ;

Shannon, M. Frances ;

Goodall, Gregory J. .

CANCER RESEARCH, 2008, 68 (19) :7846-7854

[9] Loss of Individual MicroRNAs Causes Mutant Phenotypes in Sensitized Genetic Backgrounds in C. elegans [J].

Brenner, John L. ;

Jasiewicz, Kristen L. ;

Fahley, Alisha F. ;

Kemp, Benedict J. ;

Abbott, Allison L. .

CURRENT BIOLOGY, 2010, 20 (14) :1321-1325

[10] A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells [J].

Burk, Ulrike ;

Schubert, Joerg ;

Wellner, Ulrich ;

Schmalhofer, Otto ;

Vincan, Elizabeth ;

Spaderna, Simone ;

Brabletz, Thomas .

EMBO REPORTS, 2008, 9 (06) :582-589

← 1 2 3 4 5 6 7 8 9 →