Variations in the csgD promoter of Escherichia coli O157:H7 associated with increased virulence in mice and increased invasion of HEp-2 cells

被引：80

作者：

Uhlich, GA ^{[1
]}

Keen, JE ^{[1
]}

Elder, RO ^{[1
]}

机构：

[1] USDA ARS, Roman L Hruska US Meat Anim Res Ctr, Clay Ctr, NE 68933 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 01期

关键词：

D O I：

10.1128/IAI.70.1.395-399.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Promoter alterations in the csgD gene of Escherichia coli O157:H7 strains ATCC 43894 and ATCC 43895 are associated with variations in curli expression and the ability to bind Congo red dye. Red variants of each strain were more invasive for cultured HEp-2 cells than were white variants. An ATCC 43895 red variant was more virulent than a white variant in a mouse model. However, there were no differences in Shiga toxin production between red and white variants.

引用

页码：395 / 399

页数：5

共 25 条

[1] Expression of and cytokine activation by Escherichia coli curli fibers in human sepsis
Bian, Z
Brauner, A
Li, YH
Normark, S
[J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (02) : 602 - 612
[2] Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease
Boudeau, J
Glasser, AL
Masseret, E
Joly, B
Darfeuille-Michaud, A
[J]. INFECTION AND IMMUNITY, 1999, 67 (09) : 4499 - 4509
[3] PURIFICATION AND CHARACTERIZATION OF THIN, AGGREGATIVE FIMBRIAE FROM SALMONELLA-ENTERITIDIS
COLLINSON, SK
EMODY, L
MULLER, KH
TRUST, TJ
KAY, WW
[J]. JOURNAL OF BACTERIOLOGY, 1991, 173 (15) : 4773 - 4781
[4] EPITHELIAL-CELL INVASION - AN OVERLOOKED PROPERTY OF ENTEROPATHOGENIC ESCHERICHIA-COLI (EPEC) ASSOCIATED WITH THE EPEC ADHERENCE FACTOR
DONNENBERG, MS
DONOHUEROLFE, A
KEUSCH, GT
[J]. JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (03) : 452 - 459
[5] Games P. A., 1976, J. Educ. Stat., V1, P113, DOI [10.3102/10769986001002113, DOI 10.3102/10769986001002113, DOI 10.2307/1164979]
[6] QUANTITATIVE MICROTITER CYTO-TOXICITY ASSAY FOR SHIGELLA TOXIN
GENTRY, MK
DALRYMPLE, JM
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1980, 12 (03) : 361 - 366
[7] Expression of two csg operons is required for production of fibronectin- and Congo red-binding curli polymers in Escherichia coli K-12
Hammar, M
Arnqvist, A
Bian, Z
Olsen, A
Normark, S
[J]. MOLECULAR MICROBIOLOGY, 1995, 18 (04) : 661 - 670
[8] Nucleator-dependent intercellular assembly of adhesive curli organelles in Escherichia coli
Hammar, M
Bian, Z
Normark, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) : 6562 - 6566
[9] The EspD protein of enterohemorrhagic Escherichia coli is required for the formation of bacterial surface appendages and is incorporated in the cytoplasmic membranes of target cells
Kresse, AU
Rohde, M
Guzmán, CA
[J]. INFECTION AND IMMUNITY, 1999, 67 (09) : 4834 - 4842
[10] Prevalence of Escherichia coli O157:H7 in range beef calves at weaning
Laegreid, WW
Elder, RO
Keen, JE
[J]. EPIDEMIOLOGY AND INFECTION, 1999, 123 (02) : 291 - 298

← 1 2 3 →