Implementing Personalized Medicine: Development of a Cost-Effective Customized Pharmacogenetics Genotyping Array

被引：81

作者：

Johnson, J. A. ^{[1
,2
]}

Burkley, B. M. ^{[1
]}

Langaee, T. Y. ^{[1
]}

Clare-Salzler, M. J. ^{[3
]}

Klein, T. E. ^{[4
]}

Altman, R. B. ^{[4
,5
,6
]}

机构：

[1] Univ Florida, Ctr Pharmacogenom, Dept Pharmacotherapy & Translat Res, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Med, Div Cardiovasc Med, Gainesville, FL USA

[3] Univ Florida, Dept Pathol, Gainesville, FL 32611 USA

[4] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Med, Stanford, CA 94305 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/clpt.2012.125

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe the design of a customized array built for the personalized-medicine programs of the University of Florida and Stanford University. We selected key variants for the array using the clinical annotations of the Pharmacogenomics Knowledgebase (PharmGKB), and we included variants in drug metabolism and transporter genes along with other pharmacogenetically important variants.

引用

页码：437 / 439

页数：3