Sporadic carcinoid of the stomach: a highly proliferative disease with a probable role for p53 protein dysregulation

被引：11

作者：

Peny, MO ^{[1
]}

Donckier, V ^{[1
]}

Gelin, M ^{[1
]}

Haot, J ^{[1
]}

Noel, JC ^{[1
]}

机构：

[1] Erasme Univ Hosp, Dept Pathol, B-1070 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1999年 / 11卷 / 06期

关键词：

carcinoid; MIB-1; neuroendocrine carcinoma; p53; stomach;

D O I：

10.1097/00042737-199906000-00016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We describe here one case of sporadic carcinoid of the stomach, occurring in a 65-year-old man. It is a rare, recently recognized entity, with only few cases reported in the literature. We were able to detect strong MIB-1 and p53 expression in this tumour, with 86 and 80% of tumoral cells positive, respectively. These data suggest that gastric sporadic carcinoids are a highly proliferative entity probably induced by dysregulation of p53 function. Eur J Gastroenterol Hepatol 11:677-679. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：677 / 679

页数：3

共 14 条

[1] GASTRIC CARCINOID ASSOCIATED WITH THE SYNDROME OF HYPERGASTRINEMIC ATROPHIC GASTRITIS - A PROSPECTIVE ANALYSIS OF 11 CASES [J].

BORCH, K ;

RENVALL, H ;

KULLMAN, E ;

WILANDER, E .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1987, 11 (06) :435-444

[2]

BORDI C, 1991, CANCER-AM CANCER SOC, V67, P663, DOI 10.1002/1097-0142(19910201)67:3<663::AID-CNCR2820670323>3.0.CO

[3]

2-L

[4] OAT-CELL CARCINOMA OF THE ESOPHAGUS - A CLINICOPATHOLOGICAL STUDY OF 23 CASES [J].

BRIGGS, JC ;

IBRAHIM, NBN .

HISTOPATHOLOGY, 1983, 7 (02) :261-277

[5]

COTTORETTI G, 1992, J PATHOL, V168, P357

[6]

FUKUDA T, 1988, AM J GASTROENTEROL, V83, P1176

[7] SMALL-CELL CARCINOMA OF THE STOMACH - CASE-REPORT AND REVIEW OF THE LITERATURE [J].

HUSSEIN, AM ;

OTRAKJI, CL ;

HUSSEIN, BT .

DIGESTIVE DISEASES AND SCIENCES, 1990, 35 (04) :513-518

[8]

MATSUI K, 1991, AM J GASTROENTEROL, V86, P1167

[9]

MIGNON M, 1987, CANCER, V59, P1959, DOI 10.1002/1097-0142(19870601)59:11<1959::AID-CNCR2820591120>3.0.CO

[10]

2-Z

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