Expression of cutaneous fatty acid-binding protein and its mRNA in rat skin

被引：16

作者：

Watanabe, R ^{[1
]}

Yamamoto, A ^{[1
]}

Yamaguchi, H ^{[1
]}

Takenouchi, T ^{[1
]}

Kameda, K ^{[1
]}

Ito, M ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,DEPT PSYCHIAT,NIIGATA 951,JAPAN

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1996年 / 288卷 / 08期

关键词：

cutaneous fatty acid-binding protein (C-FABP); fatty acid metabolism;

D O I：

10.1007/BF02505239

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Cutaneous fatty acid-binding protein (C-FABP) has been purified from rat skin. Since there was little information about the role of C-FABP in the skin, we investigated the expression of C-FABP and its mRNA in normal rat skin using an immunohistochemical technique and in situ hybridization, In the epidermis, C-FABP mRNA was found to be expressed in basal cells and highly in prickle cells, while C-FABP itself was strongly expressed in the upper prickle and the granular cell layers, In sebaceous glands, both C-FABP and its mRNA were expressed in both peripheral and differentiating cells, although the expression of C-FABP mRNA gradually reduced during differentiation of sebocytes. Since epidermis and sebaceous glands are active sites of fatty acid synthesis, these results suggest that C-FABP may have important roles in the transport and synthesis of fatty acids.

引用

页码：481 / 483

页数：3

共 10 条

[1]

ELIAS PM, 1991, ADV LIPID RES, V24, P1

[2]

CYTOPLASMIC FATTY-ACID BINDING-PROTEIN - SIGNIFICANCE FOR INTRACELLULAR-TRANSPORT OF FATTY-ACIDS AND PUTATIVE ROLE ON SIGNAL TRANSDUCTION PATHWAYS [J].