HIV - See a pocket, block it

被引：7

作者：

Moore, JP ^{[1
]}

Dragic, T ^{[1
]}

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

来源：

NATURE | 1999年 / 401卷 / 6755期

关键词：

D O I：

10.1038/44504

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The focus of drugs for treating HIV-1 infection has switched from protease and reverse-transcriptase inhibitors to compounds that prevent fusion of the virus with human cells. The target protein in this pathway is known as gp41, and, last year, a pocket was identified in gp41 that could act as the binding site for a fusion inhibitor. Peptide inhibitors that specifically bind this pocket have now been identified.

引用

页码：759 / 759

页数：1

共 13 条

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