Hereditary hemochromatosis in the post-HFE era

被引：57

作者：

Olynyk, John K. ^{[1
,2
,3
]}

Trinder, Debbie ^{[1
,3
]}

Ramm, Grant A. ^{[4
]}

Britton, Robert S. ^{[5
]}

Bacon, Bruce R. ^{[5
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Fremantle Hosp, Fremantle, WA 6959, Australia

[2] Fremantle Hosp, Dept Gastroenterol, Fremantle, WA, Australia

[3] Western Australia Inst Med Res, Nedlands, WA, Australia

[4] Queensland Inst Med Res, Hepat Fibrosis Grp, Brisbane, Qld 4006, Australia

[5] St Louis Univ, Ctr Liver, Dept Internal Med, Div Gastroenterol & Hepatol, St Louis, MO 63103 USA

来源：

HEPATOLOGY | 2008年 / 48卷 / 03期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1002/hep.22507

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Following the discovery of the HFE gene in 1996 and its linkage to the iron overload disorder hereditary hemochromatosis (HH) there have been profound developments in our understanding of the pathogenesis of the biochemical and clinical manifestations of a number of iron overload disorders. This article provides an update of recent developments and key issues relating to iron homeostasis and inherited disorders of iron overload, with emphasis on HFE-related HH, and is based on the content of the American Association for the Study of Liver Diseases Single-Topic Conference entitled "Hemochromatosis: What has Happened After HFE?" which was held at the Emory Convention Center in Atlanta, September 7-9, 2007.

引用

页码：991 / 1001

页数：11

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