Recent advances in hyaluronic acid based therapy for osteoarthritis

被引：241

作者：

Bowman, Steven ^{[1
]}

Awad, Mohamed E. ^{[2
]}

Hamrick, Mark W. ^{[3
,4
]}

Hunter, Monte ^{[1
]}

Fulzele, Sadanand ^{[1
,4
]}

机构：

[1] Augusta Univ, Dept Orthoped, Augusta, GA 30904 USA

[2] Augusta Univ, Dept Oral Biol, Augusta, GA USA

[3] Augusta Univ, Dept Cell Biol & Anat, Augusta, GA USA

[4] Augusta Univ, Inst Regenerat & Reparat Med, Augusta, GA USA

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2018年 / 7卷

关键词：

Osteoarthritis; Hyaluronic acid (HA); Treatment; Tissue engineering; INTRAARTICULAR SODIUM HYALURONATE; CLINICAL-PRACTICE GUIDELINES; PLATELET-RICH PLASMA; ULTRASOUND-GUIDED INJECTION; CROSS-LINKED HYALURONATE; DOUBLE-BLIND; KNEE OSTEOARTHRITIS; HIP OSTEOARTHRITIS; HYLAN G-F-20; RANDOMIZED-TRIAL;

D O I：

10.1186/s40169-017-0180-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials. It can be used as a scaffold for engineering new treatments and several new preparations have just been added to the market. A comprehensive search was conducted through several search databases according our inclusion and exclusion criteria. This review included 44 prospective clinical trial investigating the feasibility and efficacy of HA injection for knee, hip, and ankle osteoarthritis. This review will take a closer look at hyaluronic acid and its properties, as well clinical effectiveness and future options.

引用

页数：11

共 102 条

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