Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice

被引：50

作者：

Sudo, N ^{[1
]}

Yu, XN ^{[1
]}

Kubo, C ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Psychosomat Med, Higashi Ku, Fukuoka 8128582, Japan

来源：

IMMUNOLOGY LETTERS | 2001年 / 79卷 / 03期

关键词：

atopic dermatitis; dehydroepiandrosterone; IgE; interleukin-6; NC/Nga mouse; Th1/Th2; balance;

D O I：

10.1016/S0165-2478(01)00285-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Dehydroepiandrosterone (DH EA) and its sulfate derivatives are known to affect host immune function, however if such hormones influence the development of atopic dermatitis has not yet been clarified. In this study, we examined the effects of DHEA on the allergic process using NC/Nga mouse, a model animal of human atopic dermatitis. The administration of DHEA profoundly suppressed the spontaneous elevation of both serum IgE and interleukin-6 levels in NC/Nga mice during the observation period. These results indicate that DHEA promotes a shift in Th1/Th2 balance toward Th1-dominant immunity, and thus may be one of the effective alternatives in treating atopic dermatitis. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：177 / 179

页数：3

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