Wheezing bronchitis reinvestigated at the age of 10 years

被引:82
作者
Wennergren, G [1 ]
Amark, M [1 ]
Amark, K [1 ]
Oskarsdottir, S [1 ]
Sten, G [1 ]
Redfors, S [1 ]
机构
[1] OSTRA UNIV HOSP, DEPT PAEDIAT CLIN PHYSIOL, S-41685 GOTHENBURG, SWEDEN
关键词
allergy; asthma; histamine challenge; infant; passive smoking; prognosis; wheezing bronchitis;
D O I
10.1111/j.1651-2227.1997.tb09021.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We have reinvestigated 92/101 children aged 10, who before the age of 2 years were admitted to a paediatric ward due to wheezing bronchitis. At the present time, 70% are symptom-free without medication, 20% have mild asthma, 8% moderate and 2% severe asthma. Persistent asthma correlated significantly to the presence of some other atopic disease in recent yeats, to early start of wheezing during infancy and to intense obstructive disease as a young child, while initial respiratory syncytial virus infection did not. A clear-cut relationship between smoking in the home in infancy and persistent asthma emerged (not visible at a preschool follow-up). The histamine challenge results correlated to the clinical picture. A normal histamine challenge was seen in 63%, mild hyperresponsiveness in 19%, moderate in 12% and pronounced hyperresponsiveness in 6%. The figures for persistent asthma and bronchial hyperresponsiveness are high compared with the prevalence of asthma in the overall population of schoolchildren.
引用
收藏
页码:351 / 355
页数:5
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