Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine

被引：3

作者：

Grandi, T

Sparatore, F

Sparatore, A

机构：

[1] Univ Genoa, Dipartimento Sci Farmaceut, I-16132 Genoa, Italy

[2] Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy

来源：

FARMACO | 1999年 / 54卷 / 07期

关键词：

7-oxo-indolo[2,3-a]quinolizidine; anti-aggregating agents; cerebroprotective agents;

D O I：

10.1016/S0014-827X(99)00056-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The title ketone, a supposed metabolite of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (MIQ), was prepared and found different on chromatographic comparison from the isolated metabolite M-4. However, the pharmacological screening of this compound evidenced, among others, some interesting properties as inhibition of arachidonic acid induced platelet aggregation and protection from both hypobaric and cyanide induced hypoxia in mice. These activities suggest a possible cerebroprotective action to be further investigated. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：479 / 485

页数：7

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