Metabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1

被引：94

作者：

Jo, Jihoon ^{[1
]}

Heon, Seok ^{[1
]}

Kim, Myung Jong ^{[2
]}

Son, Gi Hoon ^{[1
]}

Park, Yunkyung ^{[3
]}

Henley, Jeremy M. ^{[4
]}

Weiss, Jamie L. ^{[3
]}

Sheng, Morgan ^{[2
]}

Collingridge, Graham L. ^{[4
]}

Cho, Kwangwook ^{[1
,4
]}

机构：

[1] Univ Bristol, Fac Med & Dent, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England

[2] MIT, Howard Hughes Med Inst, Picower Inst Learning & Memory, Cambridge, MA 02139 USA

[3] Univ Sheffield, Sheffield S10 2TN, S Yorkshire, England

[4] Univ Bristol, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

来源：

NEURON | 2008年 / 60卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.neuron.2008.10.050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

There are two major forms of long-term depression (LTD) of synaptic transmission in the central nervous system that require activation of either N-methyl-D-aspartate receptors (NMDARs) or metabotropic glutamate receptors (mGluRs). In synapses in the perirhinal cortex, we have directly compared the Ca2+ signaling mechanisms involved in NMDAR-LTD and mGluR-LTD. While both forms of LTD involve Ca2+ release from intracellular stores, the Ca2+ sensors involved are different; NMDAR-LTD involves calmodulin, while mGluR-LTD involves the neuronal Ca2+ sensor (NCS) protein NCS-1. In addition, there is a specific requirement for IP3 and PKC, as well as protein interacting with C kinase (PICK-1) in mGluR-LTD. NCS-1 binds directly to PICK1 via its BAR domain in a Ca2+-dependent manner. Furthermore, the NCS-1-PICK1 association is stimulated by activation of mGluRs, but not NMDARs, and introduction of a PICK1 BAR domain fusion protein specifically blocks mGluR-LTD. Thus, NCS-1 plays a distinct role in mGluR-LTD.

引用

页码：1095 / 1111

页数：17

共 56 条

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CHARACTERIZATION OF CA2+ SIGNALS INDUCED IN HIPPOCAMPAL CA1 NEURONS BY THE SYNAPTIC ACTIVATION OF NMDA RECEPTORS [J].