Translational neuroimaging: Positron emission tomography studies of monoamine oxidase

被引：58

作者：

Fowler, JS ^{[1
]}

Logan, J

Volkow, ND

Wang, GJ

机构：

[1] Brookhaven Natl Lab, Upton, NY 11973 USA

[2] Natl Inst Drug Abuse, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR IMAGING AND BIOLOGY | 2005年 / 7卷 / 06期

关键词：

monoamine oxidase; brain; tobacco smoke; PET;

D O I：

10.1007/s11307-005-0016-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs.

引用

页码：377 / 387

页数：11

共 86 条

[1] SUICIDE ENZYME INACTIVATORS [J].