Leptin binding activity changes with age: The link between leptin and puberty

被引:106
作者
Quinton, ND
Smith, RF
Clayton, PE
Gill, MS
Shalet, S
Justice, SK
Simon, SA
Walters, S
Postel-Vinay, MC
Blakemore, AIF
Ross, RJM
机构
[1] Univ Sheffield, Div Clin Sci, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Sheffield, Sch Hlth & Related Res, Sheffield S10 2TN, S Yorkshire, England
[3] Sheffield Hallam Univ, Ctr Biomed Res, Sheffield S1 1WB, S Yorkshire, England
[4] Univ Manchester, Endocrine Sci Grp, Manchester M13 9PL, Lancs, England
[5] Christie Hosp, Manchester, Lancs, England
[6] INSERM, Fac Med Necker, Unite 344, F-75730 Paris 15, France
关键词
D O I
10.1210/jc.84.7.2336
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The timing of the physical transition from child to adult is determined by a biological clock that switches off the pituitary gonadal axis during infancy until puberty. Body composition (and in particular, fat mass), through leptin, are critical signals to this clock. However, no direct relationship between leptin and puberty has been demonstrated. Leptin is bound in the circulation by a high-affinity binding protein, which has been identified as a soluble leptin receptor. We found circulating levels of leptin binding activity (LBA) to be law at birth, to be high in the prepubertal years, to fall through puberty, and then to remain stable during adult life. LBA correlated with pubertal status in both boys and girls. We postulate that the fall in LBA, associated with increasing age and puberty, reflects a reduction in expression of truncated leptin receptors, and leptin is then available to the full-length receptor, which transmits the biological signal for leptin. The high levels of LBA occur during the years when the pituitary gonadal axis is quiescent. Thus, the change in LBA could explain how leptin regulates puberty.
引用
收藏
页码:2336 / 2341
页数:6
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