学术探索
学术期刊
新闻热点
数据分析
智能评审

Azole cross-resistance in Aspergillus fumigatus

被引：93
作者：
Mosquera, J
Denning, DW
机构：
[1] Wythenshawe Hosp, Educ & Res Ctr, Dept Med, Manchester M29 9LT, Lancs, England
[2] Univ Manchester, Sch Med, Manchester M13 9PT, Lancs, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期
关键词：
D O I：
10.1128/AAC.46.2.556-557.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We susceptibility tested 17 clinical isolates of Aspergillus fumigates, for most of which MICs of itraeonazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 mug/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole. Posaconazole was the most active against itraconazole-susceptible isolates. A complex pattern of cross-resistance and hypersusceptibility was seen with voriconazole and ravuconazole, suggesting marked differences in activity and mechanisms of resistance.
引用
收藏
页码：556 / 557
页数：2
相关论文
共 12 条
  • [1] In-vivo itraconazole resistance of Aspergillus fumigatus in systemic murine aspergillosis
    Dannaoui, E
    Borel, E
    Persat, F
    Monier, MF
    Piens, MA
    [J]. JOURNAL OF MEDICAL MICROBIOLOGY, 1999, 48 (12) : 1087 - 1093
  • [2] In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole
    Dannaoui, E
    Persat, F
    Monier, MF
    Borel, E
    Piens, MA
    Picot, S
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 44 (04) : 553 - 555
  • [3] Acquired itraconazole resistance in Aspergillus fumigatus
    Dannaoui, E
    Borel, E
    Monier, MF
    Piens, MA
    Picot, S
    Persat, F
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 47 (03) : 333 - 340
  • [4] Itraconazole resistance in Aspergillus fumigatus
    Denning, DW
    Venkateswarlu, K
    Oakley, KL
    Anderson, MJ
    Manning, NJ
    Stevens, DA
    Warnock, DW
    Kelly, SL
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (06) : 1364 - 1368
  • [5] Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection
    Denning, DW
    Radford, SA
    Oakley, KL
    Hall, L
    Johnson, EM
    Warnock, DW
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (03) : 401 - 414
  • [6] Invasive aspergillosis
    Denning, DW
    [J]. CLINICAL INFECTIOUS DISEASES, 1998, 26 (04) : 781 - 803
  • [7] Optimal susceptibility testing conditions for detection of azole resistance in Aspergillus spp.:: NCCLS collaborative evaluation
    Espinel-Ingroff, A
    Bartlett, M
    Chaturvedi, V
    Ghannoum, M
    Hazen, KC
    Pfaller, MA
    Rinaldi, M
    Walsh, TJ
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) : 1828 - 1835
  • [8] A comparative study of the in vitro susceptibilities of clinical and laboratory-selected resistant isolates of Aspergillus spp. to amphotericin B, itraconazole, voriconazole and posaconazole (SCH 56592)
    Manavathu, EK
    Cutright, JL
    Loebenberg, D
    Chandrasekar, PH
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (02) : 229 - 234
  • [9] Antifungal drug resistance in Aspergillus
    Moore, CB
    Sayers, N
    Mosquera, J
    Slaven, J
    Denning, DW
    [J]. JOURNAL OF INFECTION, 2000, 41 (03) : 203 - 220
  • [10] Susceptibility testing of Aspergillus flavus:: Inoculum dependence with itraconazole and lack of correlation between susceptibility to amphotericin B in vitro and outcome in vivo
    Mosquera, J
    Warn, PA
    Morrissey, J
    Moore, CB
    Gil-Lamaignere, C
    Denning, DW
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (05) : 1456 - 1462
12