Can the exome and the immunome converge on the design of efficient cancer vaccines?

被引：18

作者：

Kroemer, Guido ^{[1
,2
,3
,4
,5
]}

Zitvogel, Laurence ^{[6
,7
,8
,9
]}

机构：

[1] INSERM, U848, Villejuif, France

[2] Inst Gustave Roussy, Metabol Platform, Villejuif, France

[3] Ctr Rech Cordeliers, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[5] Univ Paris 05, Fac Med, Paris, France

[6] Inst Gustave Roussy, Villejuif, France

[7] Inst Gustave Roussy, INSERM, U1015, F-94805 Villejuif, France

[8] IGR, Ctr Clin Invest CBT507, Villejuif, France

[9] Univ Paris 11, Villejuif, France

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 05期

关键词：

CDNA LIBRARIES; ANTIGENS; REVEALS; GENOME;

D O I：

10.4161/onci.20730

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human cancers carry hundreds of non-synonymous mutations, several dozens among which may lead to the generation of tumor-specific MHC Class I-restricted epitopes. Hence every patient's tumor harbors a highly specific mutational and antigenic signature and up to 95% of these mutations are unique. This "mutanome" can be identified by deep sequencing and can be subjected to systematic analyses of the immunogenicity of mutated proteins/peptides. We anticipate that this approach will lead to individualized immunotherapies by means of tailored vaccines.

引用

页码：579 / 580

页数：2

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