Ebola Virus Outbreak Investigation, Sierra Leone, September 28-November 11, 2014

被引：33

作者：

Lu, Hui-Jun ^{[1
]}

Qian, Jun ^{[1
]}

Kargbo, David ^{[2
]}

Zhang, Xiao-Guang ^{[3
,4
]}

Yang, Fan ^{[5
]}

Hu, Yi ^{[6
]}

Sun, Yang ^{[1
]}

Cao, Yu-Xi ^{[3
,4
]}

Deng, Yong-Qiang ^{[6
]}

Su, Hao-Xiang ^{[5
]}

Dafae, Foday ^{[2
]}

Sun, Yu ^{[6
]}

Wang, Cheng-Yu ^{[1
]}

Nie, Wei-Min ^{[7
]}

Bai, Chang-Qing ^{[8
]}

Xia, Zhi-Ping ^{[1
]}

Liu, Kun ^{[6
]}

Kargbo, Brima ^{[2
]}

Gao, George F. ^{[3
,4
]}

Jiang, Jia-Fu ^{[6
]}

机构：

[1] Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun, Peoples R China

[2] Minist Hlth & Sanitat, Freetown, Sierra Leone

[3] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[5] China & Peking Union Med Coll, Beijing, Peoples R China

[6] State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[7] 302 Hosp, Beijing, Peoples R China

[8] 307 Hosp, Beijing, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 11期

关键词：

CLINICAL-FEATURES; DISEASE;

D O I：

10.3201/eid2111.150582

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. The China Mobile Laboratory Testing Team was dispatched to support response efforts; during September 28 November 11, 2014, they conducted PCR testing on samples from 1,635 suspected EVD patients. Of those patients, 50.4% were positive, of whom 84.6% lived within a 3-km zone along main roads connecting rural towns and densely populated cities. The median time from symptom onset to testing was 5 days. At testing, 75.7% of the confirmed patients had fever, and 94.1% reported at least 1 gastrointestinal symptom; all symptoms, except rash and hemorrhage, were more frequent in confirmed than nonconfirmed patients. Virus loads were significantly higher in EVD patients with fever, diarrhea, fatigue, or headache. The case-fatality rate was lower among patients 15-44 years of age and with virus loads of <100,000 RNA copies/mL. These findings are key for optimizing EVD control and treatment measures.

引用

页码：1921 / 1927

页数：7

共 14 条

[1]

[Anonymous], 2015, EB RESP ROADM SIT RE

[2] Ebola in Freetown Area, Sierra Leone - A Case Study of 581 Patients [J].

Ansumana, Rashid ;

Jacobsen, Kathryn H. ;

Sahr, Foday .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (06) :587-588

[3] Ebola Virus Disease in West Africa - The First 9 Months of the Epidemic and Forward Projections [J].

Aylward, Bruce ;

Barboza, Philippe ;

Bawo, Luke ;

Bertherat, Eric ;

Bilivogui, Pepe ;

Blake, Isobel ;

Brennan, Rick ;

Briand, Sylvie ;

Chakauya, Jethro Magwati ;

Chitala, Kennedy ;

Conteh, Roland M. ;

Cori, Anne ;

Croisier, Alice ;

Dangou, Jean-Marie ;

Diallo, Boubacar ;

Donnelly, Christl A. ;

Dye, Christopher ;

Eckmanns, Tim ;

Ferguson, Neil M. ;

Formenty, Pierre ;

Fuhrer, Caroline ;

Fukuda, Keiji ;

Garske, Tini ;

Gasasira, Alex ;

Gbanyan, Stephen ;

Graaff, Peter ;

Heleze, Emmanuel ;

Jambai, Amara ;

Jombart, Thibaut ;

Kasolo, Francis ;

Kadiobo, Albert Mbule ;

Keita, Sakoba ;

Kertesz, Daniel ;

Kone, Moussa ;

Lane, Chris ;

Markoff, Jered ;

Massaquoi, Moses ;

Mills, Harriet ;

Mulba, John Mike ;

Musa, Emmanuel ;

Myhre, Joel ;

Nasidi, Abdusalam ;

Nilles, Eric ;

Nouvellet, Pierre ;

Nshimirimana, Deo ;

Nuttall, Isabelle ;

Nyenswah, Tolbert ;

Olu, Olushayo ;

Pendergast, Scott ;

Perea, William .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (16) :1481-1495

[4] Clinical Presentation of Patients with Ebola Virus Disease in Conakry, Guinea [J].

Bah, Elhadj Ibrahima ;

Lamah, Marie-Claire ;

Fletcher, Tom ;

Jacob, Shevin T. ;

Brett-Major, David M. ;

Sall, Amadou Alpha ;

Shindo, Nahoko ;

Fischer, William A., II ;

Lamontagne, Francois ;

Saliou, Sow Mamadou ;

Bausch, Daniel G. ;

Moumie, Barry ;

Jagatic, Tim ;

Sprecher, Armand ;

Lawler, James V. ;

Mayet, Thierry ;

Jacquerioz, Frederique A. ;

Baggi, Maria F. Mendez ;

Vallenas, Constanza ;

Clement, Christophe ;

Mardel, Simon ;

Faye, Ousmane ;

Faye, Oumar ;

Soropogui, Bare ;

Magassouba, Nfaly ;

Koivogui, Lamine ;

Pinto, Ruxandra ;

Fowler, Robert A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (01) :40-47

[5]

Fitzpatrick G, 2014, J INFECT DIS

[6] Development and evaluation of a fluorogenic 5′ nuclease assay to detect and differentiate between Ebola virus subtypes Zaire and Sudan [J].

Gibb, TR ;

Norwood, DA ;

Woollen, N ;

Henchal, EA .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (11) :4125-4130

[7] Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak [J].

Gire, Stephen K. ;

Goba, Augustine ;

Andersen, Kristian G. ;

Sealfon, Rachel S. G. ;

Park, Daniel J. ;

Kanneh, Lansana ;

Jalloh, Simbirie ;

Momoh, Mambu ;

Fullah, Mohamed ;

Dudas, Gytis ;

Wohl, Shirlee ;

Moses, Lina M. ;

Yozwiak, Nathan L. ;

Winnicki, Sarah ;

Matranga, Christian B. ;

Malboeuf, Christine M. ;

Qu, James ;

Gladden, Adrianne D. ;

Schaffner, Stephen F. ;

Yang, Xiao ;

Jiang, Pan-Pan ;

Nekoui, Mahan ;

Colubri, Andres ;

Coomber, Moinya Ruth ;

Fonnie, Mbalu ;

Moigboi, Alex ;

Gbakie, Michael ;

Kamara, Fatima K. ;

Tucker, Veronica ;

Konuwa, Edwin ;

Saffa, Sidiki ;

Sellu, Josephine ;

Jalloh, Abdul Azziz ;

Kovoma, Alice ;

Koninga, James ;

Mustapha, Ibrahim ;

Kargbo, Kandeh ;

Foday, Momoh ;

Yillah, Mohamed ;

Kanneh, Franklyn ;

Robert, Willie ;

Massally, James L. B. ;

Chapman, Sinead B. ;

Bochicchio, James ;

Murphy, Cheryl ;

Nusbaum, Chad ;

Young, Sarah ;

Birren, BruceW. ;

Grant, Donald S. ;

Scheiffelin, John S. .

SCIENCE, 2014, 345 (6202) :1369-1372

[8] Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda [J].

MacNeil, Adam ;

Farnon, Eileen C. ;

Wamala, Joseph ;

Okware, Sam ;

Cannon, Deborah L. ;

Reed, Zachary ;

Towner, Jonathan S. ;

Tappero, Jordan W. ;

Lutwama, Julius ;

Downing, Robert ;

Nichol, Stuart T. ;

Ksiazek, Thomas G. ;

Rollin, Pierre E. .

EMERGING INFECTIOUS DISEASES, 2010, 16 (12) :1969-1972

[9] Ebola Virus Disease in the Democratic Republic of Congo [J].

Maganga, Gael D. ;

Kapetshi, Jimmy ;

Berthet, Nicolas ;

Ilunga, Benoit Kebela ;

Kabange, Felix ;

Kingebeni, Placide Mbala ;

Mondonge, Vital ;

Muyembe, Jean-Jacques T. ;

Bertherat, Eric ;

Briand, Sylvie ;

Cabore, Joseph ;

Epelboin, Alain ;

Formenty, Pierre ;

Kobinger, Gary ;

Gonzalez-Angulo, Lice ;

Labouba, Ingrid ;

Manuguerra, Jean-Claude ;

Okwo-Bele, Jean-Marie ;

Dye, Christopher ;

Leroy, Eric M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (22) :2083-2091

[10]

Ministry of Health and Sanitation, EB SIT REP

← 1 2 →