Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

被引：119

作者：

Fassina, G ^{[1
]}

Buffa, A

Benelli, R

Varnier, OE

Noonan, DM

Albini, A

机构：

[1] Ist Nazl Ric Canc, I-16132 Genoa, Italy

[2] CNR, Ctr Studio Neurofisiol, Genoa, Italy

[3] Ctr Biotecnol Avanzate, Genoa, Italy

[4] Univ Genoa, Sch Med, Inst Microbiol, Genoa, Italy

来源：

AIDS | 2002年 / 16卷 / 06期

关键词：

D O I：

10.1097/00002030-200204120-00020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epigallocatechin-3-gallate (EGCG), one of the components of green tea, has been suggested to have antiviral activity. To determine the effects of EGCG on HIV infection, peripheral blood lymphocytes were incubated with either LAI/IIIB or Bal HIV strains and increasing concentrations of EGCG. EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants.

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页码：939 / 941

页数：3

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