IL-18 Serum Concentration Is Markedly Elevated in Acute EBV Infection and Can Serve as a Marker for Disease Severity

被引：48

作者：

van de Veerdonk, Frank L. ^{[1
,2
]}

Wever, Peter C. ^{[3
]}

Hermans, Mirjam H. A.

Fijnheer, Rob ^{[4
]}

Joosten, Leo A. B. ^{[1
,2
]}

van der Meer, Jos W. M. ^{[1
,2
]}

Netea, Mihai G. ^{[1
,2
]}

Schneeberger, Peter M. ^{[3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6525 GA Nijmegen, Netherlands

[2] Nijmegen Inst Infect Inflammat & Immun N4I, Nijmegen, Netherlands

[3] Jeroen Bosch Hosp, Dept Med Microbiol & Infect Control, Shertogenbosch, Netherlands

[4] Jeroen Bosch Hosp, Dept Internal Med, Shertogenbosch, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 206卷 / 02期

关键词：

EPSTEIN-BARR-VIRUS; INTERFERON-GAMMA; BINDING-PROTEIN; INTERLEUKIN-18; MONONUCLEOSIS; EXPRESSION; CYTOKINE;

D O I：

10.1093/infdis/jis335

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Epstein Barr virus (EBV)-related diseases encompass both acute infections that result in acute infectious mononucleosis and chronic infections that result in lymphoproliferative malignant diseases. While classical inflammatory parameters such as C-reactive protein (CRP) have proven their usefulness during bacterial and fungal infections, they are often low and nondiscriminatory in viral infections. Here, we show that IL-18 is markedly elevated during acute EBV infections and EBV-associated diseases, while ferritin concentrations are also elevated during acute EBV infection and correlate with IL-18. Therefore, IL-18 and ferritin may represent infection markers for viral infections such as EBV, similar to CRP for bacterial infections.

引用

页码：197 / 201

页数：5

共 15 条

[1]

A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis [J].

Balfour, HH ;

Holman, CJ ;

Hokanson, KM ;

Lelonek, MM ;

Giesbrecht, JE ;

White, DR ;

Schmeling, DO ;

Webb, CH ;

Cavert, W ;

Wang, DH ;

Brundage, RC .

JOURNAL OF INFECTIOUS DISEASES, 2005, 192 (09) :1505-1512

[2]

Dinarello CA, 2000, EUR CYTOKINE NETW, V11, P483

[3]

Laboratory assays for Epstein-Barr virus-related disease [J].

Gulley, Margaret L. ;

Tang, Weihua .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2008, 10 (04) :279-292

[4]

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 [J].

Kim, SH ;

Eisenstein, M ;

Reznikov, L ;

Fantuzzi, G ;

Novick, D ;

Rubinstein, M ;

Dinarello, CA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :1190-1195

[5]

Liu Chao-zhou, 2010, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, V26, P480

[6]

Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome [J].

Mazodier, K ;

Marin, V ;

Novick, D ;

Farnarier, C ;

Robitail, S ;

Schleinitz, N ;

Veit, V ;

Paul, P ;

Rubinstein, M ;

Dinarello, CA ;

Harlé, JR ;

Kaplanski, G .

BLOOD, 2005, 106 (10) :3483-3489

[7]

Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever [J].

Mustafa, AS ;

Elbishbishi, EA ;

Agarwal, R ;

Chaturvedi, UC .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2001, 30 (03) :229-233

[8]

Development of a real-time quantitative assay for detection of Epstein-Barr virus [J].

Niesters, HGM ;

van Esser, J ;

Fries, E ;

Wolthers, KC ;

Cornelissen, J ;

Osterhaus, ADME .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (02) :712-715

[9]

Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response [J].

Novick, D ;

Kim, SH ;

Fantuzzi, G ;

Reznikov, LL ;

Dinarello, CA ;

Rubinstein, M .

IMMUNITY, 1999, 10 (01) :127-136

[10]

Interleukin-18, interferon-γ, IP-10, and Mig expression in Epstein-Barr virus-induced infectious mononucleosis and posttransplant lymphoproliferative disease [J].

Setsuda, J ;

Teruya-Feldstein, J ;

Harris, NL ;

Ferry, JA ;

Sorbara, L ;

Gupta, G ;

Jaffe, ES ;

Tosato, G .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (01) :257-265

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