Expanding the spectrum of neuronal pathology in multiple system atrophy

被引：184

作者：

Cykowski, Matthew D. ^{[1
]}

Coon, Elizabeth A. ^{[2
]}

Powell, Suzanne Z. ^{[1
]}

Jenkins, Sarah M. ^{[3
]}

Benarroch, Eduardo E. ^{[2
]}

Low, Phillip A. ^{[2
]}

Schmeichel, Ann M. ^{[2
]}

Parisi, Joseph E. ^{[2
,4
]}

机构：

[1] Houston Methodist Hosp, Dept Pathol & Genom Med, Houston, TX 77030 USA

[2] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[3] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

来源：

BRAIN | 2015年 / 138卷

基金：

美国国家卫生研究院;

关键词：

multiple system atrophy; alpha-synuclein; neuropathology; Lewy body-like; inclusion bodies; OLIGODENDROGLIAL CYTOPLASMIC INCLUSIONS; MESSENGER-RNA EXPRESSION; ALPHA-SYNUCLEIN; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; LEWY BODIES; OLIVOPONTOCEREBELLAR SYSTEMS; HIPPOCAMPAL SCLEROSIS; BRAIN; NEUROPATHOLOGY;

D O I：

10.1093/brain/awv114

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Multiple system atrophy (MSA) is characterized clinically by parkinsonism, cerebellar dysfunction, and dysautonomia, and pathologically by glial cytoplasmic inclusions. Using pathological and clinical data from 35 patients, Cykowski <italic toggle="yes">et al. expand the spectrum of neuronal pathology in MSA and argue that neuronal inclusions have a key role in disease pathogenesis.See Halliday (doi:<related-article ext-link-type="doi" id="RA3" related-article-type="companion" xlink:href="10.1093/brain/awv151">10.1093/brain/awv151</related-article>) for a scientific commentary on this article. Multiple system atrophy (MSA) is characterized clinically by parkinsonism, cerebellar dysfunction, and dysautonomia, and pathologically by glial cytoplasmic inclusions. Using pathological and clinical data from 35 patients, Cykowski <italic toggle="yes">et al. expand the spectrum of neuronal pathology in MSA and argue that neuronal inclusions have a key role in disease pathogenesis.See Halliday (doi:<related-article ext-link-type="doi" id="RA4" related-article-type="companion" xlink:href="10.1093/brain/awv151">10.1093/brain/awv151</related-article>) for a scientific commentary on this article.

引用

页码：2293 / 2309

页数：17

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