LDI amplifications in Leishmania

被引：28

作者：

Segovia, M

Ortiz, G

机构：

来源：

PARASITOLOGY TODAY | 1997年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0169-4758(97)01111-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The genome of Leishmania is quite plastic. Chromosomal rearrangements and DNA amplifications are common events in all the species of the genus. Gene amplification occurs both as a mechanism of drug resistance and in the absence of drug pressure. The best known spontaneous amplification in Leishmania is the so-called LD1 family of amplicons. In the past few years there have been great advances in our knowledge of LD1 elements; here, Manuel Segovia and Gines Ortiz review all the available data.

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页码：342 / 348

页数：7

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