Antioxidative actions of statins: Potential mechanisms for antiathersclerotic effects

被引：12

作者：

Watanabe, T ^{[1
]}

Yasunari, K ^{[1
]}

Nakamura, M ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Med & Cardiol, Osaka 5458585, Japan

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 05期

关键词：

statins; oxidative stress; atherosclerosis; carotid artery; leukocytes; flow cytemetory;

D O I：

10.2174/138955706776876249

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.

引用

页码：505 / 508

页数：4

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