Strong antinociceptive effect of Incarvillateine, a novel monoterpene alkaloid from Incarvillea sinensis

被引：59

作者：

Nakamura, M

Chi, YM

Yan, WM

Nakasugi, Y

Yoshizawa, T

Irino, N

Hashimoto, F

Kinjo, J

Nohara, T

Sakurada, S

机构：

[1] Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 862, Japan

[2] Seiwa Pharmaceut Ltd, Kitaibaraki, Ibaraki 31915, Japan

[3] Beijing Univ Tradit Chinese Med & Pharm, Beijing 100029, Peoples R China

[4] Kagoshima Univ, Kagoshima 890, Japan

[5] Tohoku Coll Pharmaceut Sci, Dept Pharmacol, Aoba Ku, Sendai, Miyagi 981, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 09期

关键词：

D O I：

10.1021/np990041c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel monoterpene alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.

引用

页码：1293 / 1294

页数：2

共 13 条

[1]

BROWN JH, 1968, J PHARMACOL EXP THER, V160, P231

[2] STUDIES ON INCARVILLEA-SINENSIS .2. A MONOTERPENE ALKALOID FROM INCARVILLEA-SINENSIS [J].