Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst stage

被引：36

作者：

Cieslak-Janzen, Jeanine ^{[1
]}

Tur-Kaspa, Ilan ^{[1
]}

Ilkevitch, Yuri ^{[1
]}

Bernal, Alejandra ^{[1
]}

Morris, Randy ^{[1
]}

Verlinsky, Yury ^{[1
]}

机构：

[1] Illinois Masonic Med Ctr, Inst Reprod Genet, IVF & Preimplantat Genet Diag Program, Chicago, IL 60657 USA

来源：

FERTILITY AND STERILITY | 2006年 / 85卷 / 06期

关键词：

D O I：

10.1016/j.fertnstert.2005.11.059

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To determine the impact of multiple micromanipulation procedures for preimplantation genetic diagnosis (PGD) on embryo development, a retrospective analysis was performed of 9,925 embryos (862 PGD cycles), which were compared with 28,126 nonbiopsied embryos (2,751 consecutive intracytoplasmic sperm injection [ICSI] cycles) from the same time period. Because fertilization rates, the proportion of embryos with ? 6 cells on day 3, and blastocyst rates were similar in the PGD and control groups, we conclude that multiple micromanipulations on oocytes and embryos can be performed safely for PGD.

引用

页码：1826 / 1829

页数：4

共 23 条

[1]

[Anonymous], 1987, HUM GENET

[2] Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5 [J].