Pyridazine derivatives.: Part 38:: Efficient Heck alkenylation at position 5 of the 6-phenyl-3(2H)-pyridazinone system

被引：22

作者：

Coelho, A

Sotelo, C

Novoa, H

Peeters, OM

Blaton, N

Raviña, E

机构：

[1] Univ Santiago de Compostela, Fac Farm, Quim Farmaceut Lab, Dept Quim Organ, Santiago De Compostela 15782, Spain

[2] Katholieke Univ Leuven, Fac Farmaceut Wetenschappen, Lab Analyt Chem Med Fysicochem, B-3000 Louvain, Belgium

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 17期

关键词：

pyridazinones; Heck coupling; phthalazinones;

D O I：

10.1016/j.tetlet.2004.03.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 6-phenyl-3(2H)-pyridazinones bearing different alkenyl groups at position 5 have been prepared in the search for novel antiplatelet agents. The target compounds were synthesised by a palladium-catalysed Heck cross-coupling reaction. Variable amounts of 4-phenyl-6-substituted-2-phthalazinones were isolated as by-products during these experiments. The crucial issues for successful Heck coupling in these systems concern the protection of position 2 of the heterocyclic ring and the use of tris(o-tolyl)phosphine as a ligand. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3459 / 3463

页数：5

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