Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase

被引：8

作者：

Atkinson, RN ^{[1
]}

King, SB ^{[1
]}

机构：

[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(99)00509-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Guanidine-substituted imidazoles were prepared and evaluated as inhibitors of the three isoforms of nitric oxide synthase. These results identify a new 2-substituted imidazole as an isoform selective inhibitor and illustrate the possible importance of the L-arginine side chain in selective isoform recognition. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2953 / 2958

页数：6

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