Peroxisome proliferator-activated receptor agonist regulation of glial activation: Relevance to CNS inflammatory disorders

被引:84
作者
Drew, Paul D.
Xu, Jihong
Storer, Paul D.
Chavis, Janet A.
Racke, Michael K.
机构
[1] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA
[2] Univ Texas, SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75230 USA
[3] Univ Texas, SW Med Ctr Dallas, Ctr Immunol, Dallas, TX 75230 USA
关键词
microglia; astrocyte; PPAR; cytokine; neuroinflammation;
D O I
10.1016/j.neuint.2006.04.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Peroxisome proliferator-activated receptors (PPARs) play key roles in lipid metabolism and inflammation. Recent studies indicated that PPARs are also capable of modulating immune responses. Microglia and astrocytes are cells resident to the central nervous system (CNS) that function to protect against environmental insults including pathogens. However, following CNS inflammation, reactive gliosis occurs which is characterized by astrocyte hypertrophy and increased glial proliferation. Under such conditions, glia can become chronically activated and may contribute to the neuropathology associated with a variety of neuroinflammatory disorders including multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. A review of the role of PPAR agonists in modulating glial cell activation is presented. Included is a discussion of the molecular mechanisms of action of these PPAR agonists and the potential utility of these agents for the treatment of neuroinflammatory disorders. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:183 / 189
页数:7
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