One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

被引：34

作者：

Forsyth, SA ^{[1
]}

Gunaratne, HQN ^{[1
]}

Hardacre, C ^{[1
]}

McKeown, A ^{[1
]}

Rooney, DW ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Chem & Chem Engn, QUILL Res Ctr, Belfast BT9 5AG, Antrim, North Ireland

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2006年 / 10卷 / 01期

关键词：

D O I：

10.1021/op050172m

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.

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页码：94 / 102

页数：9

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