New insights into ER stress-induced insulin resistance

被引：279

作者：

Flamment, Melissa ^{[1
,2
,3
]}

Hajduch, Eric ^{[1
,2
,3
]}

Ferre, Pascal ^{[1
,2
,3
]}

Foufelle, Fabienne ^{[1
,2
,3
]}

机构：

[1] INSERM, Ctr Rech Cordeliers, Unite Mixte Rech Sante UMR S 872, F-75006 Paris, France

[2] Univ Paris 06, UMR S 872, F-75006 Paris, France

[3] Univ Paris 05, UMR S 872, F-75006 Paris, France

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 08期

关键词：

ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B; BOX-BINDING PROTEIN-1; HEPATIC STEATOSIS; SKELETAL-MUSCLE; TRANSCRIPTION FACTOR; LIVER-CELLS; CHEMICAL CHAPERONES; GLUCOSE-TRANSPORT;

D O I：

10.1016/j.tem.2012.06.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is a major characteristic of obesity and type 2 diabetes (T2DM). During the last decade, endoplasmic reticulum (ER) stress has emerged as a new player in this field and a considerable number of recent studies have pointed out its role in the onset of insulin resistance (IR). ER stress appears to act directly as a negative modulator of the insulin signaling pathway but also indirectly by promoting lipid accumulation. This review aims to summarize and decipher the abundant new literature concerning the emerging and multifaceted involvement of ER stress in the development of metabolic dysfunctions in insulin target tissues.

引用

收藏

页码：381 / 390

页数：10

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