New insights into ER stress-induced insulin resistance

被引：279

作者：

Flamment, Melissa ^{[1
,2
,3
]}

Hajduch, Eric ^{[1
,2
,3
]}

Ferre, Pascal ^{[1
,2
,3
]}

Foufelle, Fabienne ^{[1
,2
,3
]}

机构：

[1] INSERM, Ctr Rech Cordeliers, Unite Mixte Rech Sante UMR S 872, F-75006 Paris, France

[2] Univ Paris 06, UMR S 872, F-75006 Paris, France

[3] Univ Paris 05, UMR S 872, F-75006 Paris, France

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2012年 / 23卷 / 08期

关键词：

ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B; BOX-BINDING PROTEIN-1; HEPATIC STEATOSIS; SKELETAL-MUSCLE; TRANSCRIPTION FACTOR; LIVER-CELLS; CHEMICAL CHAPERONES; GLUCOSE-TRANSPORT;

D O I：

10.1016/j.tem.2012.06.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is a major characteristic of obesity and type 2 diabetes (T2DM). During the last decade, endoplasmic reticulum (ER) stress has emerged as a new player in this field and a considerable number of recent studies have pointed out its role in the onset of insulin resistance (IR). ER stress appears to act directly as a negative modulator of the insulin signaling pathway but also indirectly by promoting lipid accumulation. This review aims to summarize and decipher the abundant new literature concerning the emerging and multifaceted involvement of ER stress in the development of metabolic dysfunctions in insulin target tissues.

引用

收藏

页码：381 / 390

页数：10

相关论文

共 99 条

[51] Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis [J].

Nakamura, Takahisa ;

Furuhashi, Masato ;

Li, Ping ;

Cao, Haiming ;

Tuncman, Gurol ;

Sonenberg, Nahum ;

Gorgun, Cem Z. ;

Hotamisligil, Goekhan S. .

CELL, 2010, 140 (03) :338-U41

[52] Constitutive Role for IRE1α-XBP1 Signaling Pathway in the Insulin-Mediated Hepatic Lipogenic Program [J].

Ning, Jie ;

Hong, Tao ;

Ward, Adam ;

Pi, Jingbo ;

Liu, Zhenqi ;

Liu, Hui-Yu ;

Cao, Wenhong .

ENDOCRINOLOGY, 2011, 152 (06) :2247-2255

[53] Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans [J].

Oberkofler, H. ;

Pfeifenberger, A. ;

Soyal, S. ;

Felder, T. ;

Hahne, P. ;

Miller, K. ;

Krempler, F. ;

Patsch, W. .

DIABETOLOGIA, 2010, 53 (09) :1971-1975

[54] Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes [J].

Oezcan, Umut ;

Yilmaz, Erkan ;

Oezcan, Lale ;

Furuhashi, Masato ;

Vaillancourt, Eric ;

Smith, Ross O. ;

Goerguen, Cem Z. ;

Hotamisligil, Goekhan S. .

SCIENCE, 2006, 313 (5790) :1137-1140

[55] TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death [J].

Ohoka, N ;

Yoshii, S ;

Hattori, T ;

Onozaki, K ;

Hayashi, H .

EMBO JOURNAL, 2005, 24 (06) :1243-1255

[56] Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents [J].

Ota, Tsuguhito ;

Gayet, Constance ;

Ginsberg, Henry N. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (01) :316-332

[57] Dephosphorylation of translation initiation factor 2α enhances glucose tolerance and attenuates hepatosteatosis in mice [J].

Oyadomari, Seiichi ;

Harding, Heather P. ;

Zhang, Yuhong ;

Oyadomari, Miho ;

Ron, David .

CELL METABOLISM, 2008, 7 (06) :520-532

[58] Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes [J].

Özcan, U ;

Cao, Q ;

Yilmaz, E ;

Lee, AH ;

Iwakoshi, NN ;

Özdelen, E ;

Tuncman, G ;

Görgün, C ;

Glimcher, LH ;

Hotamisligil, GS .

SCIENCE, 2004, 306 (5695) :457-461

[59]

Ozean U, 2008, MOL CELL, V29, P541, DOI [10.1016/j.moicel.2007.12.023, 10.1016/j.molcel.2007.12.023]

[60] The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation [J].

Park, Sang Won ;

Zhou, Yingjiang ;

Lee, Justin ;

Lu, Allen ;

Sun, Cheng ;

Chung, Jason ;

Ueki, Kohjiro ;

Ozcan, Umut .

NATURE MEDICINE, 2010, 16 (04) :429-U111

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