VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus

被引：67

作者：

Yin, SH

Daum, RS

Boyle-Vavra, S

机构：

[1] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Microbiol, Chicago, IL 60637 USA

[3] Univ Chicago, Comm Mol Med, Chicago, IL 60637 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期

关键词：

D O I：

10.1128/AAC.50.1.336-343.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The VraS/VraR two-component system (VraSR) regulates transcriptional induction of penicillin-binding protein 2 (encoded by pbp2) by vancomycin in Staphylococcus aureus. We have now defined the vraSR operon and determined that its induction by beta-lactams as well as by vancomycin is autoregulated. Induction of the pbp2 and vraSR operons by beta-lactams and related compounds within 1 hour after exposure to the antimicrobials was dependent on vraS. However, when a disk diffusion assay that can detect induction of genes over an extended time period was used, induction of the pbp2 operon was mediated by some beta-lactams, including oxacillin; this induction was independent of vraS.

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页码：336 / 343

页数：8

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