Many ion channels are attractive therapeutic targets for the treatment of neurological or cardiovascular diseases; there is a continuous need for selective channel antagonists and/or agonists. Recently, several technologies have been developed that make exploration of the enormous diversity of venom-derived peptidic toxins more feasible. Integration of exogenomics with synthetic methods such as diselenide or fluorous bridges, backbone spacers, and N-to-C cyclization provides an emerging technology that promises to accelerate discovery and development of natural products based compounds. These drug-discovery efforts are complemented by novel approaches to modulate the activities of ion channels and receptors. Taken together, these technologies will advance our knowledge and understanding of ion channels and will accelerate their expansion as targets for first-in-class therapeutics.
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Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Beeton, Christine
;
Smith, Brian J.
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Smith, Brian J.
;
Sabo, Jennifer K.
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Sabo, Jennifer K.
;
Crossley, George
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Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Crossley, George
;
Nugent, Daniel
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Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Nugent, Daniel
;
Khaytin, Ilya
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Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Khaytin, Ilya
;
Chi, Victor
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Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Chi, Victor
;
Chandy, K. George
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Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Chandy, K. George
;
Pennington, Michael W.
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Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Pennington, Michael W.
;
Norton, Raymond S.
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
机构:
Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Beeton, Christine
;
Smith, Brian J.
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h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Smith, Brian J.
;
Sabo, Jennifer K.
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h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Sabo, Jennifer K.
;
Crossley, George
论文数: 0引用数: 0
h-index: 0
机构:
Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Crossley, George
;
Nugent, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Nugent, Daniel
;
Khaytin, Ilya
论文数: 0引用数: 0
h-index: 0
机构:
Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Khaytin, Ilya
;
Chi, Victor
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Chi, Victor
;
Chandy, K. George
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Chandy, K. George
;
Pennington, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Bachem Biosci Inc, King Of Prussia, PA 19406 USARoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Pennington, Michael W.
;
Norton, Raymond S.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia