Halishigamides A-D, new cytotoxic oxazole-containing metabolites from Okinawan sponge Halichondria sp.

被引：53

作者：

Kobayashi, J

Tsuda, M

Fuse, H

Sasaki, T

Mikami, Y

机构：

[1] KANAZAWA UNIV,CANC RES INST,KANAZAWA,ISHIKAWA 920,JAPAN

[2] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHIBA 280,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 02期

关键词：

D O I：

10.1021/np960558d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new oxazole-containing compounds, halishigamides A-D (1-4), have been isolated from an Okinawan marine sponge Halichondria sp. and the structures elucidated on the basis of 2D NMR data. Halishigamide A (1) is the first trisoxazole-containing macrolide possessing a primary amino group in the macrolactone ring.

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页码：150 / 154

页数：5

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