PPARγ activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes

被引：151

作者：

Pelton, PD ^{[1
]}

Zhou, LB ^{[1
]}

Demarest, KT ^{[1
]}

Burris, TP ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Dept Drug Discovery, Raritan, NJ 08869 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 261卷 / 02期

关键词：

D O I：

10.1006/bbrc.1999.1071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peroxisome-proliferator activated receptor gamma (PPAR gamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs). PPAR gamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation. PPAR gamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages. Activation of PPAR gamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions. We report that both natural and synthetic PPAR gamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1, These data suggest that PPAR gamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in adipocytes. (C) 1999 Academic Press.

引用

页码：456 / 458

页数：3

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