AMOP, a protein module aternativelly spliced in cancer cells

被引：37

作者：

Ciccarelli, FD

Doerks, T

Bork, P

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(01)02049-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article describes a new extracellular domain-AMOP for adhesion-associated domain in MUC4 and other proteins. This domain occurs in putative cell adhesion molecules and in some splice variants of MUC4. MUC4 splice variants are overexpressed in several tumours; in particular, they are highly expressed in pancreatic carcinomas but not in normal pancreas. The presence of AMOP in cell adhesion molecules could be indicative of a role for this domain in adhesion.

引用

页码：113 / 115

页数：3

共 21 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].