The first use of chiral oxazoline ligands in the highly enantioselective diethylzinc addition to diphenylphosphinoyl imines

被引：37

作者：

Zhang, XM

Lin, WQ

Gong, LZ ^{[1
]}

Mi, AQ

Cui, X

Jiang, YZ

Choi, MCK

Chan, ASC

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Union Lab Asymmetr Synth, Chengdu 610041, Peoples R China

[2] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

基金：

中国国家自然科学基金;

关键词：

diethylzinc addition; imines; oxazolines;

D O I：

10.1016/S0040-4039(02)00014-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of chiral oxazolines, which had been conveniently prepared from commercially available (1S, 2S)-2-amino-1-phenylpropane-1,3-diol, was applied in the diethylzine addition to diphenylphosphinoyl imines to give high yields of 68-84% and excellent e.e values of 90-93%. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1535 / 1537

页数：3

共 29 条

[1] Preparation and use of aziridino alcohols as promoters for the enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinoyl) imines [J].