Severe Obesity: Evidence for a Deranged Metabolic Program in Skeletal Muscle?

被引：34

作者：

Houmard, Joseph A. ^{[1
,2
,3
]}

Pories, Walter J. ^{[3
,4
]}

Dohm, G. Lynis ^{[3
,5
]}

机构：

[1] E Carolina Univ, Human Performance Lab, Coll Hlth & Human Performance, Greenville, NC 27858 USA

[2] E Carolina Univ, Dept Kinesiol, Coll Hlth & Human Performance, Greenville, NC 27858 USA

[3] E Carolina Univ, E Carolina Diabet & Obes Ctr, Greenville, NC 27858 USA

[4] E Carolina Univ, Brody Sch Med, Dept Surg, Greenville, NC 27858 USA

[5] E Carolina Univ, Brody Sch Med, Dept Physiol, Greenville, NC 27858 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2012年 / 40卷 / 04期

基金：

美国国家卫生研究院;

关键词：

bariatric surgery; exercise training; fat oxidation; Class III obesity; insulin action; mitochondria; obesity; FATTY-ACID OXIDATION; PROTEIN-KINASE-C; GLUCOSE-TRANSPORT; MORBIDLY OBESE; WEIGHT-LOSS; LIPID OXIDATION; INSULIN-RESISTANCE; RECEPTOR KINASE; ZUCKER RATS; HUMANS;

D O I：

10.1097/JES.0b013e31825d53fc

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

HOUMARD, J.A., W.J. PORIES, and G. L. DOHM. Severe obesity: evidence for a deranged metabolic program in skeletal muscle? Exerc. Sport Sci. Rev., Vol. 40, No. 4, pp. 204-210, 2012. Severe obesity is increasing at a disproportionate rate compared with milder grade obesity. Our research group has obtained evidence indicative of an "obesity metabolic program" in skeletal muscles of severely obese individuals, which may be determined genetically or epigenetically. We believe that this represents a paradigm shift in thinking about metabolic regulation in obesity.

引用

页码：204 / 210

页数：7

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