Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients

被引：63

作者：

Ding, Yi ^{[1
]}

Chen, Bin ^{[2
]}

Wang, Shuang ^{[3
]}

Zhao, Liang ^{[3
]}

Chen, Juanzhi ^{[3
]}

Ding, Yanqing ^{[3
]}

Chen, Longhua ^{[1
]}

Luo, Rongcheng ^{[2
]}

机构：

[1] So Med Univ, Dept Radiat Oncol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

[2] So Med Univ, Dept Oncol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

[3] So Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 124卷 / 03期

基金：

中国国家自然科学基金;

关键词：

hepatocellular carcinoma; Tiam1; expression; immunohistochemical analysis; prognosis; NUCLEOTIDE EXCHANGE FACTORS; RHO GTPASES; GENE; RAC; EXPRESSION; PROTEIN; ACTIVATION; ONCOGENE; SURVIVAL; ADHESION;

D O I：

10.1002/ijc.23954

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC). In this study, we investigated Tiam1 expression and its prognostic value for HCC. HCC surgical tissue samples were taken from 152 HCC patients who had been followed up for 5 years. Overexpression of Tiam1 (Tiam1 2+ to 3+) was shown in 63.8% of the cases. The Tiam1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the Tiam1 overexpression group had a significantly shorter overall survival time than the Tiam1 downexpression group (p = 0.008). Multivariate analysis showed that Tiam1 expression was a significant and independent prognostic parameter (p = 0.042) for HCC patients. Tiam1 expression may be a novel and independent predictor for the prognosis of HCC patients. (C) 2008 Wiley-Liss, Inc.

引用

页码：653 / 658

页数：6

共 37 条

[1]

Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway [J].

Bassermann, F ;

Jahn, T ;

Miething, C ;

Seipel, P ;

Bai, RY ;

Coutinho, S ;

Tybulewicz, VL ;

Peschel, C ;

Duyster, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (14) :12437-12445

[2]

Molecular viral oncology of hepatocellular carcinoma [J].

Block, TM ;

Mehta, AS ;

Fimmel, CJ ;

Jordan, R .

ONCOGENE, 2003, 22 (33) :5093-5107

[3]

Regulation of p70 S6 kinase by complex formation between the rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin [J].

Buchsbaum, RJ ;

Connolly, BA ;

Feig, LA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (21) :18833-18841

[4]

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade [J].

Buchsbaum, RJ ;

Connolly, BA ;

Feig, LA .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (12) :4073-4085

[5]

Hepatocellular carcinoma: Trends of incidence and survival in Europe and the United States at the end of the 20th century [J].

Capocaccia, Riccardo ;

Sant, Milena ;

Berrino, Franco ;

Simonetti, Arianna ;

Santi, Valentina ;

Trevisani, Franco .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (08) :1661-1670

[6]

VAV1 - A new target in pancreatic cancer? [J].

DeNicola, G ;

Tuveson, DA .

CANCER BIOLOGY & THERAPY, 2005, 4 (05) :509-511

[7]

Hepatocellular carcinoma: Recent trends in the United States [J].

El-Serag, HB .

GASTROENTEROLOGY, 2004, 127 (05) :S27-S34

[8]

Prognostic relevance of Tiam I protein expression in prostate carcinomas [J].

Engers, R. ;

Mueller, M. ;

Walter, A. ;

Collard, J. G. ;

Willers, R. ;

Gabbert, H. E. .

BRITISH JOURNAL OF CANCER, 2006, 95 (08) :1081-1086

[9]

IDENTIFICATION OF AN INVASION-INDUCING GENE, TIAM-1, THAT ENCODES A PROTEIN WITH HOMOLOGY TO GDP-GTP EXCHANGERS FOR RHO-LIKE PROTEINS [J].

HABETS, GGM ;

SCHOLTES, EHM ;

ZUYDGEEST, D ;

VANDERKAMMEN, RA ;

STAM, JC ;

BERNS, A ;

COLLARD, JG .

CELL, 1994, 77 (04) :537-549

[10]

Comparative functional analysis of the Rac GTPases [J].

Haeusler, LC ;

Blumenstein, L ;

Stege, P ;

Dvorsky, R ;

Ahmadian, MR .

FEBS LETTERS, 2003, 555 (03) :556-560

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