Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients

被引:63
作者
Ding, Yi [1 ]
Chen, Bin [2 ]
Wang, Shuang [3 ]
Zhao, Liang [3 ]
Chen, Juanzhi [3 ]
Ding, Yanqing [3 ]
Chen, Longhua [1 ]
Luo, Rongcheng [2 ]
机构
[1] So Med Univ, Dept Radiat Oncol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
[2] So Med Univ, Dept Oncol, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
[3] So Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
hepatocellular carcinoma; Tiam1; expression; immunohistochemical analysis; prognosis; NUCLEOTIDE EXCHANGE FACTORS; RHO GTPASES; GENE; RAC; EXPRESSION; PROTEIN; ACTIVATION; ONCOGENE; SURVIVAL; ADHESION;
D O I
10.1002/ijc.23954
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC). In this study, we investigated Tiam1 expression and its prognostic value for HCC. HCC surgical tissue samples were taken from 152 HCC patients who had been followed up for 5 years. Overexpression of Tiam1 (Tiam1 2+ to 3+) was shown in 63.8% of the cases. The Tiam1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the Tiam1 overexpression group had a significantly shorter overall survival time than the Tiam1 downexpression group (p = 0.008). Multivariate analysis showed that Tiam1 expression was a significant and independent prognostic parameter (p = 0.042) for HCC patients. Tiam1 expression may be a novel and independent predictor for the prognosis of HCC patients. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码:653 / 658
页数:6
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