Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives

被引：87

作者：

Campos-Toimil, M

Orallo, F

Santana, L

Uriarte, E

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Farmacol, Santiago De Compostela 15782, Galicia, Spain

[2] Univ Santiago de Compostela, Fac Farm, Dept Quim Organ, Santiago De Compostela 15782, Galicia, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(02)00015-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new and more efficient vasodilator drugs. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：783 / 786

页数：4

共 17 条

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