Regulation of Angiogenesis by Oxygen and Metabolism

被引：369

作者：

Fraisl, Peter ^{[1
,2
]}

Mazzone, Massimiliano ^{[1
,2
]}

Schmidt, Thomas ^{[1
,2
]}

Carmeliet, Peter ^{[1
,2
]}

机构：

[1] VIB, VRC, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, VRC, B-3000 Louvain, Belgium

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 02期

关键词：

ENDOTHELIAL GROWTH-FACTOR; HYPOXIA-INDUCIBLE FACTOR; ACTIVATED PROTEIN-KINASE; VASCULAR GENE-EXPRESSION; NITRIC-OXIDE; TRANSCRIPTION FACTOR; TUMOR ANGIOGENESIS; PROGENITOR CELLS; HISTONE DEACETYLASE; PPAR-ALPHA;

D O I：

10.1016/j.devcel.2009.01.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regarding the emerging crosstalk between angiogenesis and metabolism. We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism.

引用

页码：167 / 179

页数：13

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