Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats

被引：8

作者：

Alba-Loureiro, Tatiana Carolina ^{[1
]}

Pithon-Curi, Tania Cristina ^{[2
]}

Curi, Rui ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo, Brazil

[2] Cruzeiro Univ, Biol Sci & Hlth Ctr, Postgrad Program Human Movement Sci, Sao Paulo, Brazil

来源：

SHOCK | 2008年 / 30卷 / 03期

关键词：

leukocytes; diabetes; IL-1; beta; TNF-alpha; IL-10; CINC-2; alpha/beta;

D O I：

10.1097/SHK.0b013e318164e834

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

IL-1 beta, TNF-alpha, cytokine-induced neutrophil chemoattractant-2 alpha/beta, and IL-10 measurements were performed in elicited peritoneal cells from control, diabetic, and insulin-treated diabetic rats. Production/liberation of these cytokines was decreased in elicited peritoneal cells from diabetic rats. These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states.

引用

页码：308 / 310

页数：3

共 26 条

[1]

ADELAIDE M, 1987, DIABETES, V36, P1307

[2]

Diabetes causes marked changes in function and metabolism of rat neutrophils [J].

Alba-Loureiro, TC ;

Hirabara, SM ;

Mendonça, JR ;

Curi, R ;

Pithon-Curi, TC .

JOURNAL OF ENDOCRINOLOGY, 2006, 188 (02) :295-303

[3]

Role of insulin on PGE2 generation during LPS-induced lung inflammation in rats [J].

Alba-Loureiro, TC ;

Martins, EF ;

Landgraf, RG ;

Jancar, S ;

Curi, R ;

Sannomiya, P .

LIFE SCIENCES, 2006, 78 (06) :578-585

[4]

PHAGOCYTOSIS OF OPSONIZED YEAST INDUCES TUMOR-NECROSIS-FACTOR-ALPHA MESSENGER-RNA ACCUMULATION AND PROTEIN RELEASE BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

BAZZONI, F ;

CASSATELLA, MA ;

LAUDANNA, C ;

ROSSI, F .

JOURNAL OF LEUKOCYTE BIOLOGY, 1991, 50 (03) :223-228

[5]

Endotoxin-induced acute lung injury in rats. Role of insulin [J].

Boichot, E ;

Sannomiya, P ;

Escofier, N ;

Germain, N ;

Fortes, ZB ;

Lagente, V .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 1999, 12 (05) :285-290

[6]

Effects of rhG-CSF on neutrophil functions and survival in sepsis induced diabetic rats [J].

Cantürk, Z ;

Cantürk, NZ ;

Önen, F .

ENDOCRINE RESEARCH, 1998, 24 (02) :141-157

[7]

INTERLEUKIN-10 (IL-10) INHIBITS THE RELEASE OF PROINFLAMMATORY CYTOKINES FROM HUMAN POLYMORPHONUCLEAR LEUKOCYTES - EVIDENCE FOR AN AUTOCRINE ROLE OF TUMOR-NECROSIS-FACTOR AND IL-1-BETA IN MEDIATING THE PRODUCTION OF IL-8 TRIGGERED BY LIPOPOLYSACCHARIDE [J].

CASSATELLA, MA ;

MEDA, L ;

BONORA, S ;

CESKA, M ;

CONSTANTIN, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2207-2211

[8]

INTERLEUKIN-10 (IL-10) UP-REGULATES IL-1 RECEPTOR ANTAGONIST PRODUCTION FROM LIPOPOLYSACCHARIDE-STIMULATED HUMAN POLYMORPHONUCLEAR LEUKOCYTES BY DELAYING MESSENGER-RNA DEGRADATION [J].

CASSATELLA, MA ;

MEDA, L ;

GASPERINI, S ;

CALZETTI, F ;

BONORA, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (05) :1695-1699

[9]

CASSATELLA MA, 1992, J IMMUNOL, V148, P3216

[10]

THE PRODUCTION OF CYTOKINES BY POLYMORPHONUCLEAR NEUTROPHILS [J].

CASSATELLA, MA .

IMMUNOLOGY TODAY, 1995, 16 (01) :21-26

← 1 2 3 →