Distinctive immunoglobulin VH gene usage in Japanese patients with chronic lymphocytic leukemia

被引：21

作者：

Koiso, H

Yamane, A

Mitsui, T

Matsushima, T

Tsukamoto, N

Murakami, H

Miyawaki, S

Nojima, Y

Karasawa, M

机构：

[1] Gunma Univ, Sch Med, Fac Med, Blood Transfus Serv,Univ Hosp, Maebashi, Gumma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Dept Med & Clin Sci, Gunma, Japan

[3] Gunma Univ, Fac Med, Sch Hlth Sci, Gunma, Japan

[4] Saiseikai Maebashi Hosp, Gunma, Japan

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 03期

关键词：

chronic lymphocytic leukemia; immunoglobulin heavy chain gene; somatic hypermutation; V-H; 1-69; Japanese population; CD38;

D O I：

10.1016/j.leukres.2005.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of chronic lymphocytic leukemia (CLL) is low in Asian countries including Japan, while CLL is the most common type of leukemia in the west. To elucidate which factors contribute to the low frequency of CLL in Japan, we investigated immunoglobulin (Ig) heavy chain gene usage and somatic hypermutation status in 44 Japanese patients with CLL. Only one of these patients used V(H)1-69. The finding is in striking contrast to data from western countries, where the frequency of CLL expressing V(H)1-69 ranges from 12 to 21 %. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：272 / 276

页数：5

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