No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease

被引：19

作者：

Fidani, L ^{[1
]}

Compton, D

Hardy, J

Petersen, RC

Tangalos, E

Mirtsou, V

Goulas, A

De Vrieze, FW

机构：

[1] Univ Thessaloniki, Dept Gen Biol, Sch Med, GR-54006 Thessaloniki, Greece

[2] Univ Thessaloniki, Dept Pharmacol, Sch Med, GR-54006 Thessaloniki, Greece

[3] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[4] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[5] UCL, Reta Lila Weston Inst Neurol Studies, London WC2, England

[6] Inst Neurol, Dept Mol Pathogenesis, London WC2, England

[7] Mayo Clin, Dept Community Med, Rochester, MN 55055 USA

[8] Mayo Clin, Dept Neurol, Rochester, MN 55055 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 322卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; lipoprotein lipase; polymorphism; genetics;

D O I：

10.1016/S0304-3940(02)00098-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropathologically confirmed subjects. In this report we have compared the distribution of the above polymorphism in an independent group of clinically diagnosed AD patients, including a subgroup where the disease was pathologically confirmed, and a spousal control group. No statistically significant differences emerged from this comparison. We conclude that LPL cannot be a major factor in pathogenesis of AD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：192 / 194

页数：3

共 20 条

[1]

Baum L, 1999, AM J MED GENET, V88, P136, DOI 10.1002/(SICI)1096-8628(19990416)88:2<136::AID-AJMG8>3.0.CO

[2]

2-D

[3]

Baum L, 2000, MICROSC RES TECHNIQ, V50, P291, DOI 10.1002/1097-0029(20000815)50:4<291::AID-JEMT8>3.0.CO

[4]

2-L

[5]

BENZEEV O, 1990, J LIPID RES, V31, P1307

[6] SINGLE-DAY APOLIPOPROTEIN-E GENOTYPING [J].

CROOK, R ;

HARDY, J ;

DUFF, K .

JOURNAL OF NEUROSCIENCE METHODS, 1994, 53 (02) :125-127

[7]

DANIEL WW, 1999, BIOSTATISTICS FDN AN, P612

[8] Cholesterol metabolism in the brain [J].

Dietschy, JM ;

Turley, SD .

CURRENT OPINION IN LIPIDOLOGY, 2001, 12 (02) :105-112

[9] No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample [J].

Fallin, D ;

Kundtz, A ;

Town, T ;

Gauntlett, AC ;

Duara, R ;

Barker, W ;

Crawford, F ;

Mullan, M .

NEUROSCIENCE LETTERS, 1997, 233 (2-3) :145-147

[10] Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients - The Ser(447)-Stop substitution in the lipoprotein lipase gene [J].

Groenemeijer, BE ;

Hallman, MD ;

Reymer, PWA ;

Gagne, E ;

Kuivenhoven, JA ;

Bruin, T ;

Jansen, H ;

Lie, KI ;

Bruschke, AVG ;

Boerwinkle, E ;

Hayden, MR ;

Kastelein, JJP .

CIRCULATION, 1997, 95 (12) :2628-2635

← 1 2 →