Virus-specific CD4+ T cells:: ready for direct attack

被引：77

作者：

Heller, KN

Gurer, C

Münz, C

机构：

[1] Rockefeller Univ, Lab Viral Immunobiol, New York, NY 10021 USA

[2] Rockefeller Univ, Christopher H Browne Ctr Immunol & Immune Dis, New York, NY 10021 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 04期

关键词：

D O I：

10.1084/jem.20060215

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4(+) T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4(+) T cells.

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收藏

页码：805 / 808

页数：4

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