Mechanisms and therapeutic applications of immune stimulatory CpG DNA

被引：73

作者：

Krieg, AM

Yi, AK

Hartmann, G

机构：

[1] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Interdisciplinary Immunol Program, Iowa City, IA 52242 USA

[3] Vet Affairs Med Ctr, Iowa City, IA 52246 USA

[4] CpG Immunopharmaceut, Wellesley, MA USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1999年 / 84卷 / 02期

基金：

美国国家卫生研究院;

关键词：

B-cell; dendritic cell; vaccine; immunotherapy; lymphocyte activation;

D O I：

10.1016/S0163-7258(99)00023-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aside from its function as the "blueprint of life" that encodes genetic information, DNA can have direct immune activities. The immune system has evolved a defense mechanism that is able to distinguish microbial DNA from our own because of differences in the frequency and methylation of CpG dinucleotides in particular base contexts. Within minutes of detecting such "GpG-S DNA," cells of the innate immune system become activated and produce cytokines that promote the generation of antigen specific T- helper-1-like immune responses. Animal studies indicate therapeutic utility for CpG-S DNA as a vaccine adjuvant and for the immunotherapy of cancer and infectious and allergic diseases. Published by Elsevier Science Inc.

引用

页码：113 / 120

页数：8

共 65 条

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