Strict preparation and evaluation of water-soluble hatstacked carbon nanofibers for biomedical application and their high biocompatibility: influence of nanofiber-surface functional groups on cytotoxicity

被引：32

作者：

Sato, Y

Shibata, K

Kataoka, H

Ogino, S

Bunshi, F

Yokoyama, A

Tamura, K

Akasaka, T

Uo, M

Motomiya, K

Jeyadevan, B

Hatakeyama, R

Watari, F

Tohji, K

机构：

[1] Tohoku Univ, Grad Sch Environm Studies, Aoba Ku, Sendai, Miyagi 9808579, Japan

[2] Hokkaido Univ, Grad Sch Dent Med, Kita Ku, Sapporo, Hokkaido 0608586, Japan

[3] Hokkaido Univ, Grad Sch Environm Earth Sci, Kita Ku, Sapporo, Hokkaido 0600810, Japan

[4] Tohoku Univ, Grad Sch Engn, Aoba Ku, Sendai, Miyagi 9808579, Japan

来源：

MOLECULAR BIOSYSTEMS | 2005年 / 1卷 / 02期

关键词：

D O I：

10.1039/b501222h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water-soluble H-CNFs modified with a carboxyl group possessed the ability to induce TNF-alpha, whereas CHAPS-treated H-CNFs possessed significantly greater activity and were also found to activate NF-kappa B reporter activity, to a significantly greater level than H-CNFs; furthermore the functional group modified or coated on the surface of H-CNFs was a significant cytotoxic factor that affected cell activation.

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页码：142 / 145

页数：4

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